BENZOPHENONE-3
二苯酮-3
Also known as 2-Hydroxy-4-methoxybenzophenone
CAS 131-57-7EC 205-031-5PubChem CID 4632
What it is and how it is used
Classic UVA II absorber (320-370 nm) at 2-4%; good stability, but EU assessed potential endocrine disruption, limit 10%; caution in pregnancy
Status in national inventories
| China · Inventory of existing ingredients | 02091 | 按照《化妆品安全技术规范》要求使用 |
|---|---|---|
| China · STSC prohibited / restricted | CN-113/3 | 准用防晒剂(表5) · 序号 3 · 最大允许浓度 10% · 标签:含二苯酮-3 |
| EU · CosIng | 32142 | 功能 LIGHT STABILIZER, UV ABSORBER, UV FILTER · 限制 VI/4 |
| EU · Annexes to 1223/2009 | VI/4 | 附录 VI 准用防晒剂 · 序号 4 · a) Face products, hand products, and lip products, excluding propellant and pump spray products b) Body products, including propellant and pump spray products c) Other products / a) 6 % b) 2,2 % c) 0,5 % / For a) and b) |
| Brazil · ANVISA | BR-600/12 | 准用防晒剂 · RDC 600/2022 第 12 项 · 最大浓度 10% · Para concentrações maiores que 0,5% incluir advertência na rotulagem: "contém Benzophenone-3". |
Matched on the exact INCI name; salts, esters and synonyms may be missed. The latest official text prevails.
Regulatory status by market Prohibited / restricted / permitted — listing is not approval
Asia-Pacific
| Market | Status | Limit | Conditions (as published) | Source |
|---|---|---|---|---|
| KoreaMFDS | Restricted화장품 사용제한 원료 | — | 구분: 한도; 표준명: 벤조페논-3; CASNo: 131-57-7; 이명: 2-Benzoyl-5-methoxyphenol , 2-Hydroxy-4-Methoxybenzophenone , (2-Hydroxy-4-Methoxyphenyl)Phenylmethanone , Methanone, (2-Hydroxy-4-Methoxyphenyl)Phenyl- , Oxybenzone (INN); 영문명: Benzophenone-3 | kr-mfdsC · Official source |
Americas
| Market | Status | Limit | Conditions (as published) | Source |
|---|---|---|---|---|
| BrazilANVISA | PermittedUV filterRDC 600/2022 | — | 准用防晒剂 · RDC 600/2022 第 12 项 · 最大浓度 10% · Para concentrações maiores que 0,5% incluir advertência na rotulagem: "contém Benzophenone-3". | ANVISA RDC 600/2022 · transcrição Cosmetoguia(官方 gov.br/bvsmC · Official source |
| United States · CaliforniaCDPH | Listed onlyCSCP reportable ingredient | — | Reportable ingredient under the California Safe Cosmetics Act: reported to CDPH as known or suspected to cause cancer, birth defects, or other developmental or … Show full textReportable ingredient under the California Safe Cosmetics Act: reported to CDPH as known or suspected to cause cancer, birth defects, or other developmental or reproductive harm. Chemical name (as reported): Benzophenone-3; CAS 131-57-7; reported in 41 product records from 7 companies; top categories: Makeup Products (non-permanent) | Sun-Related Products | Skin Care Products; reports 2009-12-16..2018-01-30. | ca-cdphC · Official source |
EMEA
| Market | Status | Limit | Conditions (as published) | Source |
|---|---|---|---|---|
Eurasian Economic UnionEurasian Economic CommissionApplies in 5 countries / territoriesRussia · Belarus · Kazakhstan · Armenia · Kyrgyzstan | PermittedUV filterТР ТС 009/2011 Приложение 5 | leave-on 6% | 6 процентов · Не более 0,5% для защиты рецептуры · Содер-жит бензофе-нон-3 (1) | ТР ТС 009/2011 приложения 1-5, Решение Совета ЕЭК № 32 от 20C · Official source |
European UnionEuropean CommissionApplies in 30 countries / territoriesAustria · Belgium · Bulgaria · Croatia · Cyprus · Czechia · Denmark · Estonia · Finland · France · Germany · Greece · Hungary · Ireland · Italy · Latvia · Lithuania · Luxembourg · Malta · Netherlands · Poland · Portugal · Romania · Slovakia · Slovenia · Spain · Sweden · Norway · Iceland · Liechtenstein | PermittedUV filterEU Annex VI | — | 附录 VI 准用防晒剂 · 序号 4 · a) Face products, hand products, and lip products, excluding propellant and pump spray products b) Body products, including propellant and … Show full text附录 VI 准用防晒剂 · 序号 4 · a) Face products, hand products, and lip products, excluding propellant and pump spray products b) Body products, including propellant and pump spray products c) Other products / a) 6 % b) 2,2 % c) 0,5 % / For a) and b) Not more than 0,5 % to protect product formulation a) If used at 0,5 % to protect product formulation, the levels used as UV filter must not exceed 5,5 %. b) If used at 0,5 % to protect product formulation, the levels used as UV filter must not exceed 1,7 %. · 标签措辞:For a) and b): Contains Benzophenone-3 (1) ｜ ▼B ｜ 5 / Moved or deleted | EU Regulation 1223/2009 consolidated 2026-05-01 (EUR-Lex)C · Official source |
GCC Standardization OrganizationGSOApplies in 6 countries / territoriesSaudi Arabia · UAE · Oman · Qatar · Kuwait · Bahrain | PermittedUV filterGSO 1943:2021 Annex → EU Annex VI | — | 附录 VI 准用防晒剂 · 序号 4 · a) Face products, hand products, and lip products, excluding propellant and pump spray products b) Body products, including propellant and … Show full text附录 VI 准用防晒剂 · 序号 4 · a) Face products, hand products, and lip products, excluding propellant and pump spray products b) Body products, including propellant and pump spray products c) Other products / a) 6 % b) 2,2 % c) 0,5 % / For a) and b) Not more than 0,5 % to protect product formulation a) If used at 0,5 % to protect product formulation, the levels used as UV filter must not exceed 5,5 %. b) If used at 0,5 % to protect product formulation, the levels used as UV filter must not exceed 1,7 %. · 标签措辞:For a) and b): Contains Benzophenone-3 (1) ｜ ▼B ｜ 5 / Moved or deleted | GSO 1943:2021 Annex 2/3/4/5/6 → 动态引用 EU 1223/2009 附录(原文:listC · Official source |
| United KingdomOPSS | PermittedUV filterUK Annex VI | — | 2-Hydroxy-4-methoxybenzophenone/Oxybenzone · Benzophenone-3 · 131-57-7 · 205-031-5 · Product types— · (a) skin products, other than those listed in paragraph (b… Show full text2-Hydroxy-4-methoxybenzophenone/Oxybenzone · Benzophenone-3 · 131-57-7 · 205-031-5 · Product types— · (a) skin products, other than those listed in paragraph (b), including all propellant and pump spray skin products; · (b) face products, hand products and lip products (excluding propellant and pump spray face products, hand products and lip products); · (c) all other cosmetic products. · For product types— · (a) 2.2%; · (b) 6%; · (c) 0.5%. · For product types (a) and (b), not to be used at more than 0.5% to protect product formulation. · If used at 0.5% to protect product formulation, the lev · UK Annex VI · No 4 | UK Cosmetics Regulation (assimilated Regulation (EC) No 1223C · Official source |
Public regulatory text on file for 7 jurisdiction(s), covering 48 countries / territories once regional blocs are expanded. Other markets have no public data here — absence is neither approval nor prohibition. Table updated 2026-09-22.
Compiled from publicly published regulatory texts; conditions are reproduced as published, neither rewritten nor translated. The latest official announcement of the target market prevails — this table is a compiled reference, not a compliance conclusion. Matched on the INCI name; salts, esters and synonyms may be missed. Usability and labelling are for the brand and its responsible person to verify against the full text.
Literature
- Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003--2004.Environmental health perspectives · 2008
A national survey detected benzophenone-3 in 96.8% of U.S. residents' urine samples.
C · Official source - Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans.The Journal of investigative dermatology · 2004
In a whole-body application study, max plasma BP-3 was 200 ng/mL without significant hormone changes.
C · Official source
Bibliographic records and finding summaries come from public literature databases; research leads only, not efficacy claims.
Popular products with this ingredient 52 products
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Functions from EU CosIng and the China inventory; irritancy, comedogenicity and rating are our internal reading, not a regulatory conclusion. Structure and molecular data from PubChem.
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