BENZOPHENONE-4
二苯酮-4
Also known as 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
CAS 4065-45-6EC 223-772-2PubChem CID 19988
What it is and how it is used
UVA II absorber (320-370 nm) at 1-3%; slightly less stable than B3, often paired; occasional phototoxicity reports, assessment advised
Status in national inventories
| China · Inventory of existing ingredients | 02092 | 按照《化妆品安全技术规范》要求使用 |
|---|---|---|
| EU · CosIng | 32143 | 功能 LIGHT STABILIZER, UV ABSORBER, UV FILTER · 限制 VI/22 |
| Korea · Safety standards | KR-2/1127 | 附录 2 限用 · 紫外线过滤剂 · 限量 5% |
| Brazil · ANVISA | BR-600/13 | 准用防晒剂 · RDC 600/2022 第 13 项 · 最大浓度 10% (expresso como ácido) |
Matched on the exact INCI name; salts, esters and synonyms may be missed. The latest official text prevails.
Regulatory status by market Prohibited / restricted / permitted — listing is not approval
Asia-Pacific
| Market | Status | Conditions (as published) | Source |
|---|---|---|---|
| KoreaMFDS | Restricted화장품 사용제한 원료 | 구분: 한도; 표준명: 벤조페논-4; CASNo: 4065-45-6; 이명: Benzenesulfonic Acid, 5-Benzoyl-4-Hydroxy-2-Methoxy-, 5-Benzoyl-4-Hydroxy-2-Methoxybenesulfonic Acid, 5-Benzoyl-4-Hyd… Show full text구분: 한도; 표준명: 벤조페논-4; CASNo: 4065-45-6; 이명: Benzenesulfonic Acid, 5-Benzoyl-4-Hydroxy-2-Methoxy-, 5-Benzoyl-4-Hydroxy-2-Methoxybenesulfonic Acid, 5-Benzoyl-4-Hydroxy-2-Methoxybenzene Sulfonic Acid, 2-Hydroxy-4-Methoxybenzophenone-5-Sulfonic Acid, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid (Trihydrate), 1-Phenol-4-Sulfonic Acid, 2-Benzoyl-5-Methoxy-, Sulisobenzone (INN); 영문명: Benzophenone-4 | kr-mfdsC · Official source |
Americas
| Market | Status | Conditions (as published) | Source |
|---|---|---|---|
| BrazilANVISA | PermittedUV filterRDC 600/2022 | 准用防晒剂 · RDC 600/2022 第 13 项 · 最大浓度 10% (expresso como ácido) | ANVISA RDC 600/2022 · transcrição Cosmetoguia(官方 gov.br/bvsmC · Official source |
| United States · CaliforniaCDPH | Listed onlyCSCP reportable ingredient | Reportable ingredient under the California Safe Cosmetics Act: reported to CDPH as known or suspected to cause cancer, birth defects, or other developmental or … Show full textReportable ingredient under the California Safe Cosmetics Act: reported to CDPH as known or suspected to cause cancer, birth defects, or other developmental or reproductive harm. Chemical name (as reported): Benzophenone-4; CAS 4065-45-6; reported in 5 product records from 3 companies; top categories: Bath Products | Skin Care Products | Hair Care Products (non-coloring); reports 2013-10-15..2019-09-02. | ca-cdphC · Official source |
Public regulatory text on file for 3 jurisdiction(s), covering 3 countries / territories once regional blocs are expanded. Other markets have no public data here — absence is neither approval nor prohibition. Table updated 2026-09-22.
Compiled from publicly published regulatory texts; conditions are reproduced as published, neither rewritten nor translated. The latest official announcement of the target market prevails — this table is a compiled reference, not a compliance conclusion. Matched on the INCI name; salts, esters and synonyms may be missed. Usability and labelling are for the brand and its responsible person to verify against the full text.
Literature
- Acute Toxicity and Ecological Risk Assessment of Benzophenone-3 (BP-3) and Benzophenone-4 (BP-4) in Ultraviolet (UV)-Filters.International journal of environmental research and public health · 2017
In ecotoxicology, the 48h LC50 of benzophenone-4 on D. magna was observed at 47.47 mg/L.
C · Official source - Comparative study on the photostability of arbutin and deoxy arbutin: sensitivity to ultraviolet radiation and enhanced photostability by the water-soluble sunscreen, benzophenone-4.Bioscience, biotechnology, and biochemistry · 2013
In vitro, benzophenone-4 was observed to significantly improve the photostability of arbutin under UV radiation.
C · Official source - Benzophenone 4: an emerging allergen in cosmetics and toiletries?Contact dermatitis · 2007
In patch tests, positive contact dermatitis reactions to benzophenone-4 in cosmetics were observed.
C · Official source
Bibliographic records and finding summaries come from public literature databases; research leads only, not efficacy claims.
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Functions from EU CosIng and the China inventory; irritancy, comedogenicity and rating are our internal reading, not a regulatory conclusion. Structure and molecular data from PubChem.
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