CHLORHEXIDINE DIGLUCONATE
氯己定二葡糖酸盐
Also known as D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)
CAS 18472-51-0EC 617-332-2PubChem CID 9552081
What it is and how it is used
Antimicrobial agent often in oral care or antiseptics; residual odor noted; long-term use may cause resistance or sensitivity.
Status in national inventories
| China · Inventory of existing ingredients | 04528 | 按照《化妆品安全技术规范》要求使用 |
|---|---|---|
| EU · CosIng | 32659 | 功能 ANTIMICROBIAL, ORAL CARE, PRESERVATIVE · 限制 V/42 |
Matched on the exact INCI name; salts, esters and synonyms may be missed. The latest official text prevails.
Regulatory status by market Prohibited / restricted / permitted — listing is not approval
Asia-Pacific
| Market | Status | Limit | Conditions (as published) | Source |
|---|---|---|---|---|
| KoreaMFDS | Restricted화장품 사용제한 원료 | — | 구분: 한도; 표준명: 클로헥시딘다이글루코네이트; CASNo: 18472-51-0; 이명: N,N'-Bis(4-Chlorophenyl)-3,12-Diimino-2,4,11,13-Tetraazatetradecanediimidamide, Compd. with D-Gluconic Acid, … Show full text구분: 한도; 표준명: 클로헥시딘다이글루코네이트; CASNo: 18472-51-0; 이명: N,N'-Bis(4-Chlorophenyl)-3,12-Diimino-2,4,11,13-Tetraazatetradecanediimidamide, Compd. with D-Gluconic Acid, Chlorhexidine Bigluconate, Chlorhexidine Gluconate, Chlorhexidine Gluconate Solution, chlorhexidini gluconati solutio (EP), D-Gluconic Acid, Compd. with N,N'-Bis(4-Chlorophenyl)-3,12-Diimino-2,4,11,13-Tetraazatetradecanediimidamide (2:1), 1,1'-Hexamethylene Bis(5-(p-Chlorophenyl)Biguanide) Digluconate; 영문명: Chlorhexidine Digluconate | kr-mfdsC · Official source |
Americas
| Market | Status | Limit | Conditions (as published) | Source |
|---|---|---|---|---|
MercosurGrupo Mercado ComúnApplies in 4 countries / territoriesBrazil · Argentina · Uruguay · Paraguay | PermittedPreservativeGMC 35/20 (conservadores) nº 38 | leave-on 0.3% | Res. GMC 35/20 nº 38 · Bis-(p- clorofenildiguanida)- 1,6-hexano y sus acetato, gluconato y clorhidrato · 55-56-1 / 56-95-1 / 18472-51-0 / 3697-42-5 · 0,3% (expresado como clorhexidina) | Res. GMC 35/20 Lista de sustancias de acción conservadora · C · Official source |
Public regulatory text on file for 2 jurisdiction(s), covering 6 countries / territories once regional blocs are expanded. Other markets have no public data here — absence is neither approval nor prohibition. Table updated 2026-09-22.
Compiled from publicly published regulatory texts; conditions are reproduced as published, neither rewritten nor translated. The latest official announcement of the target market prevails — this table is a compiled reference, not a compliance conclusion. Matched on the INCI name; salts, esters and synonyms may be missed. Usability and labelling are for the brand and its responsible person to verify against the full text.
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Functions from EU CosIng and the China inventory; irritancy, comedogenicity and rating are our internal reading, not a regulatory conclusion. Structure and molecular data from PubChem.
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