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Dioxane

Also known as Dioxane (CAS No. 123-91-1)

CAS 123-91-1EC 204-661-8PubChem CID 31275

附录 IIIrritancy 2/5 · Comedogenic –/5Prohibited / high-risk

What it is and how it is used

附录 II

Status in national inventories

China · STSC prohibited / restrictedCN-109/490禁用原料目录(2021) · 序号 490
EU · CosIng28680附录 II · 限制 <empty>; as a constituent of other substances, or in mixtures, in concentrations equal to, or greater than 0.1% by weight; Shall not be placed on the market, or used, as substance or in mixtures in concentrations equal to ot grea
EU · Annexes to 1223/2009II/343附录 II 禁用 · 序号 343
ASEAN · Cosmetic DirectiveASEAN-II/343附录 II 禁用 · Ref 343
Indonesia · BPOMID-V/433Lampiran V · 序号 433 · ACD 343 · 123-91-1
Korea · Safety standardsKR-1/170附录 1 禁用
Canada · HotlistP-213禁用 · Prohibited

Matched on the exact INCI name; salts, esters and synonyms may be missed. The latest official text prevails.

Regulatory status by market Prohibited / restricted / permitted — listing is not approval

Asia-Pacific

MarketStatusConditions (as published)Source
ASEANASEAN Cosmetic Committee
Applies in 10 countries / territories

Singapore · Thailand · Malaysia · Indonesia · Philippines · Vietnam · Brunei · Cambodia · Laos · Myanmar

ProhibitedACD Annex II附录 II 禁用 · Ref 343ASEAN Cosmetic Directive Annexes rel. 2026-06-10 (NPRA)C · Official source
IndonesiaBPOMProhibitedBPOM Lampiran VLampiran V · 序号 433 · ACD 343 · 123-91-1Peraturan BPOM No. 17/2022 (mengubah No. 23/2019) PersyarataC · Official source
KoreaMFDSProhibited화장품 사용제한 원료구분: 금지; 표준명: 다이옥세인; CASNo: 123-91-1; 영문명: Dioxanekr-mfdsC · Official source

Americas

MarketStatusConditions (as published)Source
CanadaHealth CanadaProhibitedHotlist Prohibited禁用 · ProhibitedHealth Canada Cosmetic Ingredient HotlistC · Official source
MercosurGrupo Mercado Común
Applies in 4 countries / territories

Brazil · Argentina · Uruguay · Paraguay

ProhibitedGMC 62/14 (prohibidas) pos. 343Res. GMC 62/14 pos. 343 · DioxanoRes. GMC 62/14 Lista de sustancias prohibidas · normas.mercoC · Official source

EMEA

MarketStatusConditions (as published)Source
Eurasian Economic UnionEurasian Economic Commission
Applies in 5 countries / territories

Russia · Belarus · Kazakhstan · Armenia · Kyrgyzstan

ProhibitedТР ТС 009/2011 Приложение 1123-91-1 · 204-661-8ТР ТС 009/2011 приложения 1-5, Решение Совета ЕЭК № 32 от 20C · Official source
European UnionEuropean Commission
Applies in 30 countries / territories

Austria · Belgium · Bulgaria · Croatia · Cyprus · Czechia · Denmark · Estonia · Finland · France · Germany · Greece · Hungary · Ireland · Italy · Latvia · Lithuania · Luxembourg · Malta · Netherlands · Poland · Portugal · Romania · Slovakia · Slovenia · Spain · Sweden · Norway · Iceland · Liechtenstein

ProhibitedEU Annex II附录 II 禁用 · 序号 343EU Regulation 1223/2009 consolidated 2026-05-01 (EUR-Lex)C · Official source
GCC Standardization OrganizationGSO
Applies in 6 countries / territories

Saudi Arabia · UAE · Oman · Qatar · Kuwait · Bahrain

ProhibitedGSO 1943:2021 Annex → EU Annex II附录 II 禁用 · 序号 343GSO 1943:2021 Annex 2/3/4/5/6 → 动态引用 EU 1223/2009 附录(原文:listC · Official source
United KingdomOPSSProhibitedUK Annex IIDioxane · 123-91-1 · 204-661-8 · UK Annex II · No 343UK Cosmetics Regulation (assimilated Regulation (EC) No 1223C · Official source

Public regulatory text on file for 9 jurisdiction(s), covering 63 countries / territories once regional blocs are expanded. Other markets have no public data here — absence is neither approval nor prohibition. Table updated 2026-09-22.

Compiled from publicly published regulatory texts; conditions are reproduced as published, neither rewritten nor translated. The latest official announcement of the target market prevails — this table is a compiled reference, not a compliance conclusion. Matched on the INCI name; salts, esters and synonyms may be missed. Usability and labelling are for the brand and its responsible person to verify against the full text.

Functions from EU CosIng and the China inventory; irritancy, comedogenicity and rating are our internal reading, not a regulatory conclusion. Structure and molecular data from PubChem.

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