CLIMBAZOLE
氯咪巴唑
Tibay na kilala bilang 2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-
CAS 38083-17-9EC 253-775-4PubChem CID 37907
Ano ito at paano ito ginagamit
Antifungal preservative at 0.05–0.1%; irritating to skin/mucosa, avoid eye area and broken skin.
Katayuan sa pamasaahan ng pambansang imbentaryo
| China · Listahan ng mga kumakalang sangkap | 04531 | 按照《化妆品安全技术规范》要求使用 |
|---|---|---|
| China · Hindi pinapayagan / may pagbabawal sa STSC | CN-112/16 | 准用防腐剂(表4) · 序号 16 · 最大允许浓度 0.5% |
| UE · CosIng | 32909 | 功能 ANTI-SEBORRHEIC, ANTIMICROBIAL, PRESERVATIVE · 限制 V/32 and III/310 |
| EU · Mga aneks ng 1223/2009 | III/310 | 附录 III 限用 · 序号 310 · Rinse-off anti-dandruff shampoo (29) / 2,0 % (29) / For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product. (29) ｜ ▼M52 |
| EU · Mga aneks ng 1223/2009 | V/32 | 附录 V 准用防腐剂 · 序号 32 · (a) Hair lotions (21) (b) Face creams (21) (c) Foot care products (21) (d) Rinse-off shampoo (21) / (a) 0,2 % (21) (b) 0,2 % (21) (c) 0,2 % (21) (d) 0,5 % (21) ｜ ▼B |
| Brasil · ANVISA | BR-528/29 | 准用防腐剂 · RDC 528/2021 第 29 项 · 最大浓度 a) 0,5% em xampus com enxágue. b)0,2% em cremes faciais, loções capilares e em produtos para os pés. |
| Brasil · ANVISA | BR-530/105 | 限用 · RDC 530/2021 附件 I 第 105 项 · 适用 Agente anticaspa em xampus com enxágue. · 最大浓度 2% |
Na-match sa eksaktong INCI name; ang salts, esters at synonyms ay maaaring hindi makita. Ang pinakabagong opisyal na teksto ang nangingibabaw.
Regulatory status bawat market Ibinalang / limitado / pinapayagan — ang listing ay hindi pag-approve
Asya-Pakanlurang Karagatan
| Market | Status | Limit | Mga kondisyon (ayon sa isinalarawang) | Pinagmulan |
|---|---|---|---|---|
| Timog-kanlurang AsyaMFDS | BipigMga limitadong sangkap ng pamamagamitan | — | 구분: 한도; 표준명: 클림바졸; CASNo: 38083-17-9; 이명: 2-Butanone, 1-(4-Chlorophenoxy)-1-(1H-Imidazol-1-yl)-3,3-Dimethyl-, 1-(4-Chlorophenoxy)-1-(1H-Imidazolyl)-3,3-Dimethyl-2-Butanone, ◦climbazole (INN); 영문명: Climbazole | kr-mfdsC · Opisyal na pinagmulan |
Amerika
| Market | Status | Limit | Mga kondisyon (ayon sa isinalarawang) | Pinagmulan |
|---|---|---|---|---|
| BrazilANVISA | PinapayaganPreservativeRDC 528/2021 | — | 准用防腐剂 · RDC 528/2021 第 29 项 · 最大浓度 a) 0,5% em xampus com enxágue. b)0,2% em cremes faciais, loções capilares e em produtos para os pés. | ANVISA RDC 528/2021 · transcrição Cosmetoguia(官方 gov.br/bvsmC · Opisyal na pinagmulan |
| BrazilANVISA | BipigRDC 530/2021 | — | 限用 · RDC 530/2021 附件 I 第 105 项 · 适用 Agente anticaspa em xampus com enxágue. · 最大浓度 2% | ANVISA RDC 530/2021 · transcrição Cosmetoguia(官方 gov.br/bvsmC · Opisyal na pinagmulan |
MercosurGrupo Mercado ComúnGinagamit sa 4 bansa/teritoryoBrasil · Argentina · Uruguay · Paraguay | PinapayaganPreservativeGMC 35/20 (conservadores) nº 29 | leave-on 0.5% | Res. GMC 35/20 nº 29 · 1-(4-clorofenoxi)-1-(1- Imidazolil)-3,3-dimetil- 2-butanona(*) · 38083-17-9 · 0,5% en shampoos con enjuague. 0,2% en cremas faciales, lociones capilares y en productos para los pies. | Res. GMC 35/20 Lista de sustancias de acción conservadora · C · Opisyal na pinagmulan |
EMEA
| Market | Status | Limit | Mga kondisyon (ayon sa isinalarawang) | Pinagmulan |
|---|---|---|---|---|
Eurasian Economic UnionEurasian Economic CommissionApplies in 5 countries / territoriesRussia · Belarus · Kazakhstan · Armenia · Kyrgyzstan | PinapayaganPreservativeТР ТС 009/2011 Приложение 4 | leave-on 0.5% | 0,5 процента | ТР ТС 009/2011 приложения 1-5, Решение Совета ЕЭК № 32 от 20C · Opisyal na pinagmulan |
Unyon EuropeoEuropean CommissionEpeksibo sa 30 bansa/teritoryoAwstriya · Belhika · Bulgaria · Kroatya · Cyprus · Czechia · Denmark · Estonia · Finland · Pransiya · Germany · Greece · Hungary · Ireland · Italy · Latvia · Lithuania · Luxembourg · Malta · Netherlands · Poland · Portugal · Romania · Slovakia · Slovenia · Espanya · Sweden · Norway · Iceland · Liechtenstein | PinapayaganPreservativeEU Annex V | — | 附录 V 准用防腐剂 · 序号 32 · (a) Hair lotions (21) (b) Face creams (21) (c) Foot care products (21) (d) Rinse-off shampoo (21) / (a) 0,2 % (21) (b) 0,2 % (21) (c) 0,2 % (21) (d) 0,5 % (21) ｜ ▼B | EU Regulation 1223/2009 consolidated 2026-05-01 (EUR-Lex)C · Opisyal na pinagmulan |
GCC Standardization OrganizationGSONababigyan ng impluwensya sa 6 bansa/teritoryoArabia Saudita · UAE · Oman · Qatar · Kuwait · Bahrain | PinapayaganPreservativeGSO 1943:2021 Annex → EU Annex V | — | 附录 V 准用防腐剂 · 序号 32 · (a) Hair lotions (21) (b) Face creams (21) (c) Foot care products (21) (d) Rinse-off shampoo (21) / (a) 0,2 % (21) (b) 0,2 % (21) (c) 0,2 % (21) (d) 0,5 % (21) ｜ ▼B | GSO 1943:2021 Annex 2/3/4/5/6 → 动态引用 EU 1223/2009 附录(原文:listC · Opisyal na pinagmulan |
| United KingdomOPSS | BipigUK Annex III | — | 1-(4-Chlorophenoxy)- 1-(imidazol-1-yl)-3,3- dimethylbutan-2-one · Climbazole · 38083-17-9 · 253-775-4 · Rinse-off anti-dandruff shampoo · 2,0 % · For purposes o… Ipakita ang buong teksto1-(4-Chlorophenoxy)- 1-(imidazol-1-yl)-3,3- dimethylbutan-2-one · Climbazole · 38083-17-9 · 253-775-4 · Rinse-off anti-dandruff shampoo · 2,0 % · For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product. · UK Annex III · No 310 | UK Cosmetics Regulation (assimilated Regulation (EC) No 1223C · Opisyal na pinagmulan |
Public regulatory text on file for 7 jurisdiction(s), covering 51 countries / territories once regional blocs are expanded. Other markets have no public data here — absence is neither approval nor prohibition. Table updated 2026-09-22.
Ginawa mula sa mga pampubliko na regulasyon; ang mga kondisyon ay inilaan ayon sa orihinal na publikasyon, hindi isinulat muli o isulat. Ang pinakabagong opisyal na anunsyo ng target market ang may kapangyarihan — ang talahanayan na ito ay isang na-compile na sanggunian, hindi isang konklusyon sa compliance. Tinulakay ang INCI name; maaaring maiwan ang mga asin, ester, at sinonimo. Ang paggamit at pagpapalamat ay para sa brand at sa kanyang responsible person na pumansinlaban sa buong teksto.
Literatura
- Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An in Silico and in Vitro Study.Environmental health perspectives · 2020
In silico and in vitro studies observed Climbazole binding to various nuclear receptors and affecting their activity.
C · Opisyal na pinagmulan - Analysis of transcriptional response in zebrafish eleutheroembryos exposed to climbazole: Signaling pathways and potential biomarkers.Environmental toxicology and chemistry · 2019
In zebrafish embryo exposure, Climbazole was observed to down-regulate transcription of circadian and steroidogenesis genes.
C · Opisyal na pinagmulan - Topical delivery of climbazole to mammalian skin.International journal of pharmaceutics · 2018
In transdermal delivery studies, observed that solvent types significantly influence Climbazole skin permeation rates.
C · Opisyal na pinagmulan - Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole.International journal of cosmetic science · 2013
In dandruff shampoo formulations, Climbazole was observed to enhance anti-Malassezia activity and improve sensory properties.
C · Opisyal na pinagmulan
Mula sa mga publikong base ng literatura ang mga bibliyografikong talaan at buod ng paghahanap; tungo lamang sa pananaliksik, hindi klase ng kapangyarihan ng gamot.
Mga popular na produkto na may sangkap na ito 4 produkto
Mga function mula sa EU CosIng at China inventory; ang irritancy, comedogenicity at rating ay ang aming internal na pagbabasa, hindi regulatory na konklusyon. Ang structure at molecular data mula sa PubChem.
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